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Tetracyclines including doxycycline, minocycline, lymecycline being unsafe in the second and third trimester of pregnancy vide supra are best avoided at all stages of pregnancy, whereas oral retinoids being highly teratogenic are absolutely contraindicated.
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also, patients who have some liver disease or dysfunction should avoid alcohol and minocycline as both substances are metabolized by the liver and they can be very harmful for the liver if they are taken for a long period of time.
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